Toward Public Health & Safe Society
General Toxicology Test
General toxicology is the most basic and main toxicity test that can predicted the toxicity of new test substance. To investigate the risk of test substances (agricultural pesticide, drug, industrial chemical and other environmental pollutants) to human, test animals(rat, mouse, rabbit, guinea pig, dog, monkey etc.) are used to conduct assessment on the risk on all organ tissues including circulatory, digestive, respiratory, urinary, reproductive, nervous system by injecting single or multiple times.
Field of Test
"We conduct toxicity test as below using test animals(rat, mouse, rabbit, guinea pig, dog, monkey etc.) in accordance with domestic and overseas GLP Guideline regarding the toxicity assessment of various chemicals such as existing and new drug, agricultural pesticide and chemicals."
Single Dose Toxicity Test
- Assess toxicity by checking the acute changes such as general symptoms, weight, autopsy after injecting a test substance single time or fractional dose within 24 hours to rodents, non-rodents and non-human primate.
Repeated Dose Toxicity Test
- Assess toxicity by drawing up the NOAEL, target organ and dose-toxicity reaction relation by checking general symptom, weight, feed intake, water intake, ECG and conducting visual check, hematological and blood biochemical test, urine test, autopsy, organ weight measurement, histopathological test and toxicokinetics analysis after repeatedly injecting test substance to rodents, non-rodents and non-human primate.
Continuous Infusion Toxicity Test using Infusion Pump
- Infusion injection test to vein in short time based on method of restraint
- After attaching retainer to rodents, non-rodents and non-human primate, 4 weeks of repeated injection on in vein infusion is available for rats(1 hour), dogs and monkeys(1 days 4 hours).
- Infusion injection test to vein for 24 hours with catheter insertion
- Insert catheter to vein of rat and dog, and use swivel and infusion pump to inject in vein infusion for maximum 24 hours a day for 4 weeks.
- Local irritation test
- Oral, dermal, vein, subcutaneous, intradermal, muscular, abdominal administration
- Sample biopsy specimen such as blood and urine, and manage long-term culture