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General Toxicology

일반독성시험

General Toxicology

General toxicology study is the most basic set of tests to predict toxicity of test articles such as chemicals or biologics including drugs, agricultural, industrial products and environmental pollutants, in order to assess the potential toxicity of test articles in human, the effects of test articles on organ system (gastrointestinal, respiratory, urinary, reproductive and nervous system etc.) are evaluated in single and repeated dose toxicity studies using animals such as rats, mice, rabbitys, guinia pigs, dogs, and non-human primates.

Testing field

In order to evaluate the portential toxicities of existing or new drugs, pesticides and various chemicals, the following toxicity tests are conducted using lavoratory animals in accordance with international GLP guidelines.

Single Dose Toxicity Test

The assessment for toxicity is conducted by single administration or multiple administrations of test articles within 24 hours to rodents, non-rodents and non-human primates, and reviewing acute changes such as clinical signs, body weights or gross observations and if necessary, histopathologic examination.

Repeated Dose Toxicity Test

Test articles are administered repeatedly to test animals. Various parameters such as clinical signs, body weights, food consumption, water consumption, electrocardiogram, ophthalmology, hematology, coagulation, clinical chemistry, urinalysis, gross observations, organ weights, histopathology, toxicokinetics and immunology are conducted to get No Observed Adverse Effect Level (NOAEL), target organs or; the relationship between the systemic exposure of test articles in test animals and its toxicity.

Continuous Infusion Toxicity Test using Infusion Pump

Service Contents

  • Single Dose Toxicity Test :
    Oral, Dermal, Intravenous, Subcutaneous, Intradermal, Intramuscular, Intraperitoneal, Intratracheal, Intrathecal, Intracerebral
  • Repeated Dose Toxicity Test :
    Oral, Dermal, Intravenous, Subcutaneous, Intradermal, Intramuscular, Intraperitoneal, Intratracheal, Intrathecal, Intracerebral
  • Local Irritation Test :
    Intravenous, Dermal, Subcutaneous, Intradermal, Intramuscular
  • Continuous Administration Toxicity Test :
    Intravenous
  • Collecting Blood and Urine for Toxicokinetics